HD icon won't open with the mouse

I installed Tiger yesterday. Then I updated to 10.4.4, added a few new widgets from Apple downloads. Everything is running more slowly than 10.2.8 and my mouse is not able to open the Mac HD icon on the desktop. I cannot open my IDisk icon from the desktop either. I am able to open both of them by going to "GO" and pulling down the menu. The MAC HD appears to have a very faint blue box around it when I try to open it. I have tried other icons on the desktop and I can't open them either. I can click on items in the DOCK and they do work. I do not understand this problem at all! I have also tried to click on the MAC OS X install DVD and it does not open either.

Thank you all for your help. I did go in and tinker with the Mouse in system preferences and in universal access. The Mouse is still erratic, but working much better. I'm going back now and try to really speed it up. That may solve this last little crazy behavior.
I-Mac Mac OS X (10.4.4) 30 GB free space

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