Help! "4.7.0 Temporary server error. Please try again later. PRX4"

I am in the process of migrating a single Exchange 2013 install (CAS+MBX co-located) to two separate installs, a CAS and MBX server. Mail has been flowing in via my new CAS for around a week now, I had altered DNS and IPs for this. Yesterday I migrated
the last mailboxes off the old server and then un-installed Exchange, which appeared to happen cleanly and without issue. I am now facing an issue where my CAS server will not receive emails, reporting "4.7.0
Temporary server error. Please try again later. PRX4" when I try to send an email. If I send emails directly to the MBX server, they arrive without issue.
This was working before I removed the old Exchange server. Any ideas? I'm really stuck here.

Hello,
Please use the following test tool to check the root cause:
https://testconnectivity.microsoft.com/
Thanks,
Please remember to mark the replies as answers if they help and unmark them if they provide no help. If you have feedback for TechNet Subscriber Support, contact
[email protected]
Simon Wu
TechNet Community Support

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