Help! Can't open any files....

I don't know if it is a coincidence or not but I downloaded 10.4.4 a few days ago and ever since have not been able to open any files. Double-clicking on anything on the desktop is greeted with a resounding.....nothing. Opening e-mails is impossible. Playing more than one track on itunes is impossible. It feels like the Mini has had a stroke, with only Safari being accessible. I have tried running a hardware test with the CD, but that won't open either. Restarts achieve nothing. Any suggestions? Or am I going to have to take it for repair?

Have you tried repairing permissions ?
If not, then go to Applications > Utilities, launch Disk Utility, select your hard drive (Macintosh HD unless you renamed it or boot off an external FireWire HD) and click on Repair Disk Permissions.
And if it still doesn't work, you might want to download and run a small 3rd-party utility such as Yasu which will perform maintenance/troubleshooting tasks such as clearing logs, system and font caches etc.
Mac mini1.25 Ghz G41 GB RAM40 GB HDDAirPort Extreme   Mac OS X (10.4.4)   External 250 GB LaCie HDDLaCie FW DVD-RW DL 16x20 GB iPod w/Color Display

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