HELP! Error (-50) appearing when trying to sync ipod and shuffle

The story so far....
My ipod has recently been playing up (cutting songs short etc), at the same time I bought a shuffle online. When I recently plugged both of these into my itunes it's been playing up. Im not sure if this is just coincidence or if the shuffle/ipod classic are not working.
Whe  trying to sync my itunes with either of my devices I get so far then they both come up with the unknown error (-50).
I have been reading all the support from previous discussions and have tried the following but with no avail!!
Removed and reinstalled itunes as per apple recommnedations
removed all security protection from my computer
Checked apple mobile device USB
Restored ipod classic to factory settings (now no music on it!!!)
I have been through "Help > run diagnostics" and it looks like the ipod is recognised sometimes and not others
I have checked the SMART data:
Retracts: 1
Reallocs 8528
Pending Sectors: 112
Power On hours: 29
Start/Stop: 4501
Temp Min: 10c
Temp Max: 56c
I have all my music on an external hardrive. I have a PC laptop with Windows XP. I have previously had no problems with syncing itunes etc. Im worried about plugging my iphone 4 into my computer in case anything else goes wrong would I be able to?
Previously some music was transferring on (manually) but then it slowed right down and gave me the (-50) error and when I disconnected the ipod (did not eject but never have done previously) all the music was gone!
Please please please help before I lose the will!!!
Many thanks in advance for anyone who knows their itunes/ipod inside out!
JCC

I have also done this:
regsvr32 /s softpub.dll
    regsvr32 /s wintrust.dll
    regsvr32 /s dssenh.dll
    regsvr32 /s rsaenh.dll
    regsvr32 /s gpkcsp.dll
    regsvr32 /s sccbase.dll
    regsvr32 /s slbcsp.dll
    regsvr32 /s mssip32.dll
    regsvr32 /s cryptdlg.dll
    regsvr32 /s initpki.dll
as per apple support.

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