HELP!! iTunes audio configuration

When opening my iTunes, I got a box saying: iTunes has detected a problem with your audio configuraiton. Audio/Video playback may not operate properly. I clicked on a song to play to hear how it sounded, but song never played at all. Can someone please help me with this? I haven't upgraded to 7.7 yet...still using 7.6.
Thanks.

I'd definitely try Meg's suggestion first.
However, if no joy with that, launch your "Sounds and Audio Devices" control panel and click on the "Audio" tab. Is the correct default device showing up in your "Sound playback" area?

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