Help! Mail freeze: window won't open, nor will it close so I can restart

I've just had a strange problem with Mail. The window won't open - or has issues with opening (it did, but only briefly). It's generally having problems - its menus aren't dropping down - and I would like to quit and restart the computer (a Mac Mini). I've tried an apple q and nothing is happening. So the computer won't restart unless I force a shut down by manually holding down the button.
Any suggestions most welcome…

'''mcaleck'''
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