Help!!! my iphone 4 will not open any of my contacts also some of my settings or twitter, and will not sync will itunes .... what do i do ?

hey can someone help me please
my twitter app will not open or my setting and contacts, aslo my iphone will not sync with itunes

Basic troubleshooting of the device from the User's Guide is reset, restart, restore.  Has any of this been tried?

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