Help setting up an efficient AE/Premiere workflow.

Question

I am working on several AE/Premiere projects on a Pavilion M6 laptop and have a few drives that I can use for media storage/cache/exporting and am wonding what will be best way to use each one, or if I even need to. My internal drive is a Sandisk SSD 3Gb/s, my second drive is a WD MyPassport 256GB USB 2.0 5400RPM HDD, and my third is a Sandisk Cruzer Extreme 32GB USB 3.0 flash drive. I'm on a HP Pavilion M6-1035DX if you need any system specs to make a determination. I currently have all of my files on the MyPassport (because the Cruzer Extreme flash drive isn't here yet), and am wondering if I should:
keep the media files on the MyPassport, run AE & Premiere (and store the cache) on my internal SSD, and export to the Cruzer Extreme (when it gets here)
or, move my media and project files to the Cruzer Extreme and run AE & Premiere (and store the cache) on my internal SSD because the SSD is faster than the USB 2.0 drive (connection and read/write speeds, USB 2.0 vs SATAII and SSD vs 5400RPS HDD)
or, move my media and project files to the Cruzer Extreme, run AE & Premiere on my internal SSD, and store the cache on my MyPassport (so it's not on the same drive as my project files, programs, or media)
or, some other configuration I haven't thought of
I have ready in many places that you should use three drives for video editing and motion graphics, but because there are so many technologies and potential bottlenecks involved I want to make sure I do it right/efficiently.

Answer 1

First I wanted to say "thank you for all of the excellent answers and info". It is incredibly difficult for me to choose the 'correct' answer as so many people gave me excellent information and suggestions. I ended up keeping my programs, media files, and media cache & database on my internal SSD. I put my preview files on my flash drive, which is also where I put my export folder (which I learned from watching part of a After Effects & Premiere Pro Performance Workshop video). Since I'm not exporting video while I'm editing, and I'm not previewing my project while I'm exporting a project, this made a lot of sense to do. I will mark the last answer as correct just because it helped me the most being able to see the "priority rank-numbers for speed, with 1 for the fastest volume and 5 for the least speed-demanding category".The one thing I would ask 'cc_merchant', is if you could re-clarify the list so it shows which files are read the most, require the fastest read speeds, and when/how often they're being read; as well as another list that does the same for write speeds. I still don't completely understanding exactly what data is being read/written when, and exactly how much. If data cache & database (for instance) is being read from constantly, it may make sense to put it on my flash drive, since nothing is currently being read from it while I edit (if that makes sense). I do like the fact that my project files and original media are in the same folder, and would like to keep it that way if at all possible. I also bench-marked my SSD and flash drive, and know that I get excellent read speeds from my SSD and excellent write speeds on my flash drive. Although, I can also read and write to and from both simultaneously.
I actually just purchased a 2nd USB 3.0 flash drive (64GB, my other is 32GB), and am going to configure it as suggested in this similar discussion Generic Guideline for Disk Setup. The first posting there really answered my question the best so far, and if someone would have posted it here I would have definitely marked it as correct immediately. I would highly recommend checking out that discussion if you're new to configuring your Premiere Pro or After Effects workflow. It is a simple list that tells you where to put your files for the best performance based on how many drives you have.
Thanks again for all of your help!