Help - since 15:00 this afternoon Port 25 timed out and no mail can be sent

Have been sending and receiving mail all day - suddenly with no warning or reason mail cannot be sent from either my account or my wife's (on the same computer using the same ADSL line. The message is that "This message could not be delivered......The connection "smtp.mac.com" on port 25 timed out. All outgoing mail is blocked.

Read the following article, which applies to all versions of Mac OS X (not just Mac OS X 10.4.2 and earlier as the article states) and can be useful for other mail accounts as well (not just .Mac):
.Mac: Server timeout alert message when sending email

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