HELP! "This file is damaged and cannot be repaired."

I have been editing a large (25+ MB) PDF in Adobe Acrobat X Pro on a Macbook.
I just tried to open it to continue editing and got an error message:
"This file is damaged and cannot be repaired."
What on earth happened?!?!
A few days ago I saved a compressed version that is 1/10th the size. I can use that if I absolutely have to (it means losing part of my work and not all of my work) but I'm nervous -- what is the difference between a compressed file and a standard file that would make the compressed file 10% of the size? Is it fully functional with edits?
Ideally, if someone could help me remedy my error problem on the main file, that would be preferable -- but I'll also take info on compressed files (I didn't zip it, I just saved it in "Finder" as a compressed file.)

Lara,
yes it said something like "some fonts are not supported..etc...would you like to open the file anyway." (sry cant remember verbatim...I had a friend of mine try to open it on her comp which has cs3).
I believe CS3 should substitute the fonts in question, or at least give you the option to substitute them. Did you try saving it from CS3 (with or without font substitution) and then opening in CS4 as I suggested?
CS4 may be more particular than CS3 when it comes to fonts. Illy is more particular than most applications (some applications open files with corrupt fonts that she flatly refuses), and she may have become more particular over the years.

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    From: [email protected]
    To: [email protected]
    Subject: the muse file is damaged and cannot be opened
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