Help! Won't start without internal Audio hard drive

So here's the issue.
I've been having some problems with my internal Audio hard drive where it will randomly un-mount and I think it might be causing crashes. Anyway, I decided I'd just take it out and use an external drive. When I did that and tried to restart, the computer just loses power. It tries to start and then just shuts off, I never even get anything on my screen.
If I reinstall the drive, the computer starts up.
Also, when I take the drive out, it refuses to start from an external drive or a dvd.
I've tried resetting the PRAM, the NVRAM and the Open Firmware with no results.
Any help would be greatly appreciated.
Thanks,
Stephen

Yeah, there is. It seems to work fine when the second drive is hooked up and I've made sure it's set up as the boot drive in system preferences. The drive I'm using as the Audio drive is actually the original hard drive that came with the system and the boot drive is a newer SATA drive.
Also, while both internal drives are hooked up, the computer will start either from a DVD or an external hard drive no problem.

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