Hi, I can't open After Effects. Error: 131:4

Hi I can't open my After Effects CS5. I get the error message Error: 131:4.  I recently upgraded to Photoshop and Lightroom CC, could this have affected it?
Thanks
Chau

Mac OSX v10.9.3 is not a supported operating system for After Effects CS5.
See the system requirements:
System requirements | After Effects

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