High number of BizTalk applications

Are there any concerns to be aware of with having a hundreds (in the range of 300-500) BizTalk applications hosted in a single BizTalk group? From say administration, maintenance or deployment perspective.  Appreciate any input.

The more of anything the harder it is to manage.
Is 500 BizTalk Applications a specific problem?  No, but it could indicate other 'issues' with how the apps/solutions are organized.
The question to ask yourself, are there really 300-500 separate and distinct apps?
Or, are there groups of apps that function together?  If so, you may consider putting those into one Application.

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