Hissing and crackling through ITunes on MacBook Pro.

Funny that most complaints about this issue are from people running ITunes through their PC's. I have the same problem through ITunes on my Mac. Play music through VLC player and it plays perfectly!!

What about Quicktime Player?  I don't know how much of QT VLC uses and I'm trying to test under different configurations.
Other general suggestions (not a bad idea to back up before experimenting but none of below is risky):
Start iTunes in safe mode -
     iTunes Safe Mode - http://hints.macworld.com/article.php?story=20090915214613484
     iTunes: Troubleshooting issues with third-party iTunes plug-ins - http://support.apple.com/kb/TS3430 - hold down the Option and Command keys (on Mac OS X) or holding down the Shift and Control keys (on Windows) while opening iTunes
Start the computer in Safe Mode, test iTunes:
     Mac OS X: Starting up in Safe Mode - http://docs.info.apple.com/article.html?artnum=107393
     What is Safe Boot, Safe Mode? (Mac OS X) - http://support.apple.com/kb/HT1564
Verify and/or repair drive and permissions with Disk Utility.
Re-install system updates.
Re-install iTunes software.

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