How can I make a file a more manageable size?

I'm looking to downsize a very hefty file.  It currently has a lot of information and is clumsy to deal with when attaching to email, opening it up, printing, etc.  Is there a straightforward way to save a version of this document with ONLY the information it needs to print a high quality image?  It doesn't need to be edited after downsizing, it just needs to look virtually the same after printing (8.5x11) as it would with all the file info intact.  Ideally, the resolution would allow for zooming in (maybe 300-400%?  That's totally arbitrary though...) on-screen without super visible pixelation.  Essentially, I think I'm looking for a way to create a high-quality "picture" of this illustrator document without significantly altering its appearance in print (priority) or on-screen.  The requested format is PDF, but I think that's flexible if an alternative is better.  I don't have a target file size, just hoping to find a mechanism that allows me to play with it until I find the minimum MB for maximum print quality.
Don't know if it's useful, but part of the reason it's so large is that I had to consolidate it into one file, so I had to embed raster images and a couple fonts (although I later just made outlines) that were links while I was actively working on it.
Thanks in advance for any insight!

Thank you!  That was a great recommendation.  "Smallest File Size" seems to bring the raster images all the way down to 150 dpi, which is a little low for my purposes, but I'll continue to play around with the other options in that dropdown menu.
Thanks again for your time.

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