How can I replace my start up hard drive in mac pro 2008?

Mi hd is geting old and I am worry about loosing Everything any time how can I replace my HD without reinstaling Every single Aplications?
Any Advice thanks.

Clone it.
Or install OS X and it will ask to use Setup Assistant and import everything when it sees another system drive.
Use cloning as a backup method.
Keep only the OS and apps and a small user library on the boot drive.
Now is a good time to invest in an SSD for your system.
A new drive for data and media files.
Use your existing drive(s) as backups and pull them once the system and data are copied, cloned, and moved over.
Use TimeMachine for some file backup as well.
Clone your system:
How to Clone a Volume
Using Cloning as a Backup Strategy 
See also Erasing a Drive, How and Why to Partition a Drive, RAID.
http://www.macupdate.com/app/mac/7032/carbon-copy-cloner

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