How can I speed up my sluggish MacBook Pro?

I installed Mavericks last year and my MacBook Pro seems to be getting more and more sluggish, especially with the Adobe Creative Suite. Lately InDesign has been crashing on a regular basis. I used to be able to run several programs simultaneously, but now have to be cautious. Any suggestions?

I was running EtreCheck when I saw your reply. :-) Here are the results.
Problem description:
sluggish performance
EtreCheck version: 2.1.8 (121)
Report generated February 23, 2015 at 9:29:17 AM CST
Download EtreCheck from http://etresoft.com/etrecheck
Click the [Click for support] links for help with non-Apple products.
Click the [Click for details] links for more information about that line.
Hardware Information: ℹ️
    MacBook Pro (13-inch, Mid 2009) (Technical Specifications)
    MacBook Pro - model: MacBookPro5,5
    1 2.53 GHz Intel Core 2 Duo CPU: 2-core
    4 GB RAM Upgradeable
        BANK 0/DIMM0
            2 GB DDR3 1067 MHz ok
        BANK 1/DIMM0
            2 GB DDR3 1067 MHz ok
    Bluetooth: Old - Handoff/Airdrop2 not supported
    Wireless:  en1: 802.11 a/b/g/n
    Battery Health: Normal - Cycle count 20
Video Information: ℹ️
    NVIDIA GeForce 9400M - VRAM: 256 MB
        Apple Studio Display 1280 x 1024
System Software: ℹ️
    OS X 10.9.5 (13F34) - Time since boot: 2 days 17:46:40
Disk Information: ℹ️
    Hitachi HTS545025B9SA02 disk0 : (250.06 GB)
        EFI (disk0s1) <not mounted> : 210 MB
        Macintosh HD (disk0s2) / : 249.20 GB (56.12 GB free)
        Recovery HD (disk0s3) <not mounted>  [Recovery]: 650 MB
    HL-DT-ST DVDRW  GS23N 
USB Information: ℹ️
    Seagate BUP Slim SL 2 TB
        Seagate Backup Plus Drive (disk4s1) /Volumes/Seagate Backup Plus Drive : 2.00 TB (1.96 TB free)
    Apple Inc. Built-in iSight
    LaCie Minimus USB 3 1 TB
        EFI (disk3s1) <not mounted> : 210 MB
        BACKUP (disk3s2) /Volumes/BACKUP : 999.86 GB (341.00 GB free)
    Seagate  Desktop          2 TB
        Raven (disk1s1) /Volumes/Raven : 537.01 GB (460.16 GB free)
        Greenstone (disk1s2) /Volumes/Greenstone : 1.02 TB (908.14 GB free)
        Untitled 3 (disk1s3) /Volumes/Untitled 3 : 443.20 GB (2.78 GB free)
    Apple, Inc. Keyboard Hub
        Apple, Inc Apple Keyboard
     composite_device 7.76 GB
        SFI 8 GB (disk2s1) /Volumes/SFI 8 GB : 7.76 GB (7.41 GB free)
    Brother HL-2040 series
    Apple Internal Memory Card Reader
    Apple Inc. Apple Internal Keyboard / Trackpad
    Apple Computer, Inc. IR Receiver
    Apple Inc. BRCM2046 Hub
        Apple Inc. Bluetooth USB Host Controller
Gatekeeper: ℹ️
    Anywhere
Kernel Extensions: ℹ️
        /Library/Extensions
    [not loaded]    com.microsoft.VirtualPC.Networking (7.0.1) [Click for support]
    [not loaded]    com.microsoft.VirtualPC.OSServices (7.0.1) [Click for support]
        /System/Library/Extensions
    [not loaded]    com.Mouse.driver.MouseSetting (1.0.1) [Click for support]
    [not loaded]    com.NCHSoftware.driver.SoundTapVirtualAudioDevice (1.0.0d1) [Click for support]
    [not loaded]    com.lexar.iokit.IOSCSILexarCommandsDevice (1.1.2) [Click for support]
    [not loaded]    com.lexarmedia.driver.IOUSBJumpshotClass (1.0.1) [Click for support]
    [not loaded]    com.wacom.kext.wacomtablet (6.0.5) [Click for support]
    [not loaded]    jp.co.epson.driver.EpsonNet_PSUSBNotSeize (1.0.0) [Click for support]
    [loaded]    net.telestream.driver.TelestreamAudio (1.0.5 - SDK 10.6) [Click for support]
Startup Items: ℹ️
    AdobeVersionCueCS2: Path: /Library/StartupItems/AdobeVersionCueCS2
    PACESupport: Path: /Library/StartupItems/PACESupport
    VirtualPCOSServices: Path: /Library/StartupItems/VirtualPCOSServices
    Startup items are obsolete in OS X Yosemite
Launch Agents: ℹ️
    [not loaded]    com.adobe.AAM.Updater-1.0.plist [Click for support]
    [loaded]    com.oracle.java.Java-Updater.plist [Click for support]
    [failed]    com.wacom.wacomtablet.plist [Click for support]
Launch Daemons: ℹ️
    [loaded]    com.adobe.fpsaud.plist [Click for support]
    [loaded]    com.adobe.SwitchBoard.plist [Click for support]
    [loaded]    com.oracle.java.Helper-Tool.plist [Click for support]
    [loaded]    com.oracle.java.JavaUpdateHelper.plist [Click for support]
User Launch Agents: ℹ️
    [loaded]    com.adobe.AAM.Updater-1.0.plist [Click for support]
    [loaded]    com.adobe.ARM.[...].plist [Click for support]
    [loaded]    com.google.keystone.agent.plist [Click for support]
User Login Items: ℹ️
    Garmin Express Service    Application  (/Applications/Garmin Express.app/Contents/Library/LoginItems/Garmin Express Service.app)
    Backup Engine 3    Application Hidden (/Library/Application Support/Maxtor/Backup Engine 3.app)
    iTunesHelper    Application Hidden (/Applications/iTunes.app/Contents/MacOS/iTunesHelper.app)
    Dropbox    Application  (/Applications/Dropbox.app)
    Google Chrome    Application Hidden (/Applications/Google Chrome.app)
    laciebackupd    Application  (/Library/Application Support/LaCie/LaCie Backup/laciebackupd.app)
Internet Plug-ins: ℹ️
    PandoWebInst: Version: 1.0 [Click for support]
    Default Browser: Version: 537 - SDK 10.9
    Flip4Mac WMV Plugin: Version: 3.0.0.85 BETA  - SDK 10.7 [Click for support]
    OfficeLiveBrowserPlugin: Version: 12.2.0 [Click for support]
    Google Earth Web Plug-in: Version: 6.1 [Click for support]
    CouponPrinter-FireFox: Version: Version 1.0.11
    FlashPlayer-10.6: Version: 16.0.0.305 - SDK 10.6 [Click for support]
    NP2020Player: Version: 4.5.2.0 [Click for support]
    Silverlight: Version: 5.1.30317.0 - SDK 10.6 [Click for support]
    Flash Player: Version: 16.0.0.305 - SDK 10.6 [Click for support]
    iPhotoPhotocast: Version: 7.0
    QuickTime Plugin: Version: 7.7.3
    GarminGpsControl: Version: 4.1.0.0 Release - SDK 10.7 [Click for support]
    JavaAppletPlugin: Version: Java 7 Update 75 Check version
User internet Plug-ins: ℹ️
    fbplugin_1_0_3: Version: Unknown [Click for support]
Safari Extensions: ℹ️
    Weather
    F.B. Purity - Cleans Up Facebook
    InvisibleHand
    HoverSee
    Facebook Photo Zoom
    Social Fixer
3rd Party Preference Panes: ℹ️
    Adobe Version Cue CS2  [Click for support]
    Déjà Vu  [Click for support]
    Flash Player  [Click for support]
    Flip4Mac WMV  [Click for support]
    Growl  [Click for support]
    Java  [Click for support]
    Media Booster  [Click for support]
    Mouse Preference  [Click for support]
    StuffIt AVR  [Click for support]
Time Machine: ℹ️
    Skip System Files: NO
    Mobile backups: ON
    Auto backup: YES
    Volumes being backed up:
        Greenstone: Disk size: 1.02 TB Disk used: 112.05 GB
        Raven: Disk size: 537.01 GB Disk used: 76.85 GB
        Untitled 3: Disk size: 443.20 GB Disk used: 440.42 GB
        Macintosh HD: Disk size: 249.20 GB Disk used: 193.08 GB
    Destinations:
        BACKUP [Local]
        Total size: 999.86 GB
        Total number of backups: 15
        Oldest backup: 2015-02-06 23:09:00 +0000
        Last backup: 2015-02-23 12:02:14 +0000
        Size of backup disk: Too small
            Backup size 999.86 GB < (Disk used 822.40 GB X 3)
Top Processes by CPU: ℹ️
         9%    WindowServer
         3%    Finder
         1%    backupd
         0%    AppleSpell
         0%    aosnotifyd
Top Processes by Memory: ℹ️
    90 MB    mds_stores
    60 MB    Safari
    56 MB    mds
    47 MB    com.apple.WebKit.WebContent
    39 MB    Finder
Virtual Memory Information: ℹ️
    991 MB    Free RAM
    662 MB    Active RAM
    1.34 GB    Inactive RAM
    591 MB    Wired RAM
    21.17 GB    Page-ins
    1.13 GB    Page-outs
Diagnostics Information: ℹ️
    Feb 22, 2015, 04:43:56 PM    /Users/[redacted]/Library/Logs/DiagnosticReports/Adobe Illustrator_2015-02-22-164356_[redacted].crash
    Feb 20, 2015, 03:37:22 PM    Self test - passed
    Feb 20, 2015, 02:39:02 PM    /Users/[redacted]/Library/Logs/DiagnosticReports/Adobe Illustrator_2015-02-20-143902_[redacted].crash
    Feb 16, 2015, 11:47:51 AM    /Library/Logs/DiagnosticReports/Kernel_2015-02-16-114751_[redacted].panic [Click for details]

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