How can I upload a non-macstore app

I have a bayer glucometer and it has software that will not install on my mac.  The system tells me that it cannot load non-macstore apps.  When I try to go to system preferences, they're grayed out, so I can't do anything.  I'd really like to use the program.  Any ideas how I can get my system to make the adjustment to accept this app?

Can you Ctrl (Right) click the Application & choose 'Open' ?.
Dtails here : OS X: About Gatekeeper

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