How come I cannot update my iTunes to the latest version?

How come I cannot update my iTunes to the latest version?
Whenever I click the setup icon, nothing happens.
Or when I click "Check for updates" in iTunes, nothing happens too.
Can anyone tell me what's wrong? And what should I do?

Many thanks.
It seems unlikely that McAfee is causing the damage here. But it may be interpreting the installer damage as indicating an unsafe package. (The damage is causing the file to not be properly digitally signed.)
Perhaps try downloading and saving a copy of the installer to a different PC. (If you're on a 32-bit Windows system, try to download on a different 32-bit Windows system.) Copy the iTunesSetup.exe installer to an external hard-drive, or a large-enough thumb drive or burn it to a CD-R. Carry the installer back to your PC, copy the installer to your hard drive. (Don't run the install from the ExHD, thumb or CD-R.) Start the install by doubleclicking the iTunesSetup.exe file.

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