How do I avoid the "can't save to disk" notice when updating LION?

I've tried to update Lion 3 times (through Software Update) and after 2 hours of downloading it gives me a notice that it can't "save to disk."  I have 80 gigs available on my harddrive so I don't know what I'm doing wrong.  Please HELP!

Thanks for showing an interest… But!
     I have tried all the regular stuff. This problem only showed up in OSX Lion. Up till then all was well at Snow Leopard and Adobe CS5.5 Suite. After upgrading to OSX Lion all Hell broke loose. Quite a catastrophe of conflicts. In Design wouldn’t launch. A problem with Suitcase Fusion 4. But PS CS6 had two major problems. One the Epson Artisan 835 could not be seen in Imports. A conflict between 32 and 64 bit formats and again, drivers. But the most persistent and perplexing problem has been that of the preferences. Oh and one other thing, whenever you quit the program, PS CS6, a message appears saying that the program has quit for no good reason and did I want to send a report to Adobe and/or Mac. Well I must have sent them a thousand reports. What I most suspect is file damage and incompatibility. What I have tried has not found the files to replace those that will reset themselves. i.e. .plst etc. without buggering up the works. I have tried to figure out what might have caused such changes between Snow and Lion other than the well known differences regarding supported stuff, formats and out of date software i.e. Rosetta. Some how or other I suspect damaged files. The kind of damage where a single character is missing and nothing works but no file checker in the world can detect as screwing up the works. Now in several cases a lot of re-installation has been done. But again no help. So putting a finger on the culprit file(s) has not been easy. Fortunately this machine has four active drives so reverting back to where all was OK is easy. But as for going forward, well that is at a standstill.
    So, if any body out there has any insight to these three problems I would be most interested to see what you got.
Many Thanks

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    Thanks for showing an interest… But!
         I have tried all the regular stuff. This problem only showed up in OSX Lion. Up till then all was well at Snow Leopard and Adobe CS5.5 Suite. After upgrading to OSX Lion all Hell broke loose. Quite a catastrophe of conflicts. In Design wouldn’t launch. A problem with Suitcase Fusion 4. But PS CS6 had two major problems. One the Epson Artisan 835 could not be seen in Imports. A conflict between 32 and 64 bit formats and again, drivers. But the most persistent and perplexing problem has been that of the preferences. Oh and one other thing, whenever you quit the program, PS CS6, a message appears saying that the program has quit for no good reason and did I want to send a report to Adobe and/or Mac. Well I must have sent them a thousand reports. What I most suspect is file damage and incompatibility. What I have tried has not found the files to replace those that will reset themselves. i.e. .plst etc. without buggering up the works. I have tried to figure out what might have caused such changes between Snow and Lion other than the well known differences regarding supported stuff, formats and out of date software i.e. Rosetta. Some how or other I suspect damaged files. The kind of damage where a single character is missing and nothing works but no file checker in the world can detect as screwing up the works. Now in several cases a lot of re-installation has been done. But again no help. So putting a finger on the culprit file(s) has not been easy. Fortunately this machine has four active drives so reverting back to where all was OK is easy. But as for going forward, well that is at a standstill.
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