How do I find out which app is using an item of hardware?

(This question may or may not require knowledge of Protools audio program to answer.)
When I try to load Protools 6.4 on my Mac, I get an error message (number 1133) saying that the DAE (Digital Audio Engine, I assume) is already being used by another app. The Avid (owner of Protools) website is of no help since it merely says to close the conflicting program, and believe it or not, some glitch prevents me from logging into their forum. So I'm hoping the Mac forum can help.
I learn from the only manual I have (Switching to the Mac: Snow Leopard edition by David Pogue: Yes, I know, I need to buy a Tiger manual)that the problem could be something loaded in the Login Items list in System Preferences > Accounts but I have gotten rid of all those. Or maybe something in Library > Startup Items or System > Library > Extensions. But there were only three items in the former (Digidesign Loader, NetGEARWLANClient Utility, and PACESupport), all of which I have moved to the trash. There are a gigantic number of items in the latter directory, and I moved only NegTEARWLANClient Utility to the trash since it least it has the same name as one of the others, though ostensibly ought not to matter.
But I still get the 'Digidesign hardware is in use by another application' error.
My manual by Pogue suggests a Safe Boot achieved by holding down the Shift key to prevent loading of the extensions, but apparently that had yet been implemented in Tiger since it doesn't work.
Having written the above, it just occurred to me to leave the Digidesign hardware unplugged till after I boot the Mac. However, before trying that, I'll post what I have so far (for fear of losing it if there's a power outage).

the problem could be something loaded in the Login Items list in System Preferences > Accounts but I have gotten rid of all those.
A question, did you just uncheck them or highlight them & click the little minus icon? Do they still show in the list? I'm not sure, but I don't think it takes effect until you restart.
Should anyone else come across this - the message is typical of not having the proper version of Pro Tools installed for the OS version being used.
In this case, the minimum Pro Tools version supported on OS 10.4.10 is 6.9.2 (or 6.8.1 with certain Digi hardware devices).
http://duc.digidesign.com/showthread.php?t=226330
See also...
http://duc.digidesign.com/showthread.php?t=139150
http://duc.digidesign.com/showthread.php?t=138097
http://www.macosxaudio.com/forums/viewtopic.php?f=26&t=40980

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