How do I fix the workspace error "because the file is locked, you do not have necessary access permissions..."?

I keep getting the error message "Could not apply the workspace because the file is locked, you do not have necessary access permissions, or another program is using the file. ..." when I try to open a workspace. Any ideas how to fix the permissions and what file does not have permissions. I am on a Mac.

See here:
CS5 "Locked"

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