How do I get past, "Can't save preferences message" in PS CS6?

Could not save Preferences because the file is locked, you do not have necessary access permissions, or another program is using the file. Use the ‘Get Info’ command in the Finder to ensure the file is unlocked and you have permission to access the file. If the problem persists, save the document to a different file or duplicate it in the Finder.
Get me past this message. Please! Nothing I have read applies exactly to eliminating this infuriating message. How do I get past, “Can’t save preferences message” in PS CS6?
Message was edited by: RustyBucket12

Thanks for showing an interest… But!
I have tried all the regular stuff. This problem only showed up in OSX Lion. Up till then all was well at Snow Leopard and Adobe CS5.5 Suite. After upgrading to OSX Lion all Hell broke loose. Quite a catastrophe of conflicts. In Design wouldn’t launch. A problem with Suitcase Fusion 4. But PS CS6 had two major problems. One the Epson Artisan 835 could not be seen in Imports. A conflict between 32 and 64 bit formats and again, drivers. But the most persistent and perplexing problem has been that of the preferences. Oh and one other thing, whenever you quit the program, PS CS6, a message appears saying that the program has quit for no good reason and did I want to send a report to Adobe and/or Mac. Well I must have sent them a thousand reports. What I most suspect is file damage and incompatibility. What I have tried has not found the files to replace those that will reset themselves. i.e. .plst etc. without buggering up the works. I have tried to figure out what might have caused such changes between Snow and Lion other than the well known differences regarding supported stuff, formats and out of date software i.e. Rosetta. Some how or other I suspect damaged files. The kind of damage where a single character is missing and nothing works but no file checker in the world can detect as screwing up the works. Now in several cases a lot of re-installation has been done. But again no help. So putting a finger on the culprit file(s) has not been easy. Fortunately this machine has four active drives so reverting back to where all was OK is easy. But as for going forward, well that is at a standstill.
So, if any body out there has any insight to these three problems I would be most interested to see what you got.
Many Thanks

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