How do I know if the caches are doing what they should be?

A while back my computer suddenly slowed down a lot. I downloaded an activity monitor program to see if I could identify the problem. I found that no matter what was running or not running, the file cache always takes up any remaining memory I have. I keep seeing people saying on forums that the caches speed your computer up, they save time by saving app info, it doesn't help to delete them, etc. And yet, my computer takes ten times as long as it should to do anything. Is it possible that way more things are trying to be cached than there should be? People keep saying they are there to speed up the computer, but no matter what I do, it seems like that is the problem. Is there any way to verify that the cached files are the problem, or if it's something else?

Ok, here is the EtreCheck report. Here it is saying I have a significant amount of free RAM, but I don't know if there is a difference between virtual memory and RAM.
EtreCheck version: 2.1.8 (121)
Report generated March 27, 2015 at 3:21:26 PM EDT
Download EtreCheck from http://etresoft.com/etrecheck
Click the [Click for support] links for help with non-Apple products.
Click the [Click for details] links for more information about that line.
Hardware Information: ℹ️
    iMac (21.5-inch, Late 2013) (Technical Specifications)
    iMac - model: iMac14,1
    1 2.7 GHz Intel Core i5 CPU: 4-core
    8 GB RAM Upgradeable
        BANK 0/DIMM0
            4 GB DDR3 1600 MHz ok
        BANK 1/DIMM0
            4 GB DDR3 1600 MHz ok
    Bluetooth: Good - Handoff/Airdrop2 supported
    Wireless: en1: 802.11 a/b/g/n/ac
Video Information: ℹ️
    Intel Iris Pro
        iMac 1920 x 1080
System Software: ℹ️
    OS X 10.10.2 (14C1514) - Time since boot: 4:18:34
Disk Information: ℹ️
    APPLE HDD HTS541010A9E662 disk0 : (1 TB)
        EFI (disk0s1) <not mounted> : 210 MB
        Macintosh HD (disk0s2) / : 999.35 GB (545.15 GB free)
        Recovery HD (disk0s3) <not mounted> [Recovery]: 650 MB
USB Information: ℹ️
    Apple Inc. FaceTime HD Camera (Built-in)
    Apple Inc. BRCM20702 Hub
        Apple Inc. Bluetooth USB Host Controller
    Apple, Inc. Keyboard Hub
        Apple Inc. Apple Keyboard
    Mitsumi Electric Apple Optical USB Mouse
Thunderbolt Information: ℹ️
    Apple Inc. thunderbolt_bus
Gatekeeper: ℹ️
    Mac App Store and identified developers
Kernel Extensions: ℹ️
        /Applications/System Center 2012 Endpoint Protection.app
    [not loaded]    com.microsoft.kext.scep_kac (4.5.15) [Click for support]
        /System/Library/Extensions
    [not loaded]    com.marvell.kext.USBGenericPrinterClass (1.0.0) [Click for support]
Launch Daemons: ℹ️
    [loaded]    com.adobe.fpsaud.plist [Click for support]
    [loaded]    com.DesignScience.DSMTTool.plist [Click for support]
    [loaded]    com.microsoft.office.licensing.helper.plist [Click for support]
    [running]    com.microsoft.scep_daemon.plist [Click for support]
    [loaded]    com.oracle.java.JavaUpdateHelper.plist [Click for support]
    [running]    com.secunia.csia.plist [Click for support]
User Launch Agents: ℹ️
    [loaded]    com.adobe.ARM.[...].plist [Click for support]
    [running]    com.hp.printerAgent.plist [Click for support]
User Login Items: ℹ️
    iTunesHelper    Application (/Applications/iTunes.app/Contents/MacOS/iTunesHelper.app)
    Dropbox    Application (/Applications/Dropbox.app)
    System Center 2012 Endpoint Protection    Application (/Applications/System Center 2012 Endpoint Protection.app)
Internet Plug-ins: ℹ️
    Flip4Mac WMV Plugin: Version: 3.2.0.16   - SDK 10.8 [Click for support]
    FlashPlayer-10.6: Version: 16.0.0.305 - SDK 10.6 [Click for support]
    Default Browser: Version: 600 - SDK 10.10
    AdobePDFViewerNPAPI: Version: 10.1.12 [Click for support]
    AdobePDFViewer: Version: 10.1.12 [Click for support]
    Flash Player: Version: 16.0.0.305 - SDK 10.6 Outdated! Update
    QuickTime Plugin: Version: 7.7.3
    SharePointBrowserPlugin: Version: 14.4.5 - SDK 10.6 [Click for support]
    Silverlight: Version: 5.1.30317.0 - SDK 10.6 [Click for support]
    DirectorShockwave: Version: 12.0.4r144 - SDK 10.6 [Click for support]
3rd Party Preference Panes: ℹ️
    Flash Player [Click for support]
    Flip4Mac WMV [Click for support]
Time Machine: ℹ️
    Time Machine not configured!
Top Processes by CPU: ℹ️
        11%    mds_stores
         8%    ARM
         2%    WindowServer
         2%    launchservicesd
         1%    launchd
Top Processes by Memory: ℹ️
    60 MB    mds_stores
    52 MB    com.apple.WebKit.WebContent
    52 MB    Safari
    43 MB    Finder
    34 MB    mds
Virtual Memory Information: ℹ️
    5.17 GB    Free RAM
    1.54 GB    Active RAM
    517 MB    Inactive RAM
    974 MB    Wired RAM
    141.55 GB    Page-ins
    22.73 GB    Page-outs
Diagnostics Information: ℹ️
    Mar 27, 2015, 11:01:49 AM    Self test - passed
    Standard users cannot read /Library/Logs/DiagnosticReports.
    Run as an administrator account to see more information.

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