How do i resolve "An unknown error occurred (-42110)?

when launching iTunes on my new Win8 laptop, it give the error box
An unknown error occurred (-42110)
iTunes appears to 'work' ok, but my real library (which is on my external hard drive) does not seem to be found - even tho looking in the advanced settings for library location appears to be pointing to the external drive.
Yes, I have home sharing turned on
Yes the other laptop (WinXP) works just fine, with no errors.
Confused...?

Some discussion on means of locating the SC Info folder on Windows 8 systems in the following topic:
TS1389 Re: How can you do this in windows 8?

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