How do I sync my two iphones (my wifes and mine) with itunes not to mix apps and contacts

When connecting two iphones after each other the information from one 4s will sync on the second 3gs iphone. How to use one itunes on the same pc with two iphones not to mix every data the both tltphones have? Thank You!

If you have separate windows user profile, each profile will maintain their own data. You can create outlook account for your wife in her profile and your account on your profile, it will not mix up.
Refer to this article for information:
Multiples Devices on one computer:
http://support.apple.com/kb/HT1495

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