How do you delete apps in the sync list?

When I sync my computer and phone there is a list of apps that I no longer use.  I don't need them there and I definitely don't want them there.  Some of the apps are ones I downloaded one time and will never download again.  Any way to get rid of them?

Shirley,
     Go to itunes, go to upper left hand corner and hit A, then hit my apps. Right click or control/click and hit delete. Done!
Good Luck. 
Tommy

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