How to change read-only status in excel

I've got an Excel file on my desktop that I've tinkered with for months.  All of a sudden when I go back to reopen it, the message says, "The file may be read-only, or you may be trying to access a read-only location.  Or, the server the document is stored on may not be responding."  The choices are either "cancel," or "retry."  Both avail nothing.
What the heck is going on?  I can't even open it in order to  "toy" with it in Excel settings, Preferences, etc etc !
Your help is most appreciated.

I've got an Excel file on my desktop that I've tinkered with for months.  All of a sudden when I go back to reopen it, the message says, "The file may be read-only, or you may be trying to access a read-only location.  Or, the server the document is stored on may not be responding."  The choices are either "cancel," or "retry."  Both avail nothing.
What the heck is going on?  I can't even open it in order to  "toy" with it in Excel settings, Preferences, etc etc !
Your help is most appreciated.

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