How to correct "The application "Safari" can't be opened."

When I try to open Safari, I get this message and then, there is the -600.

A couple of things.
First off, does this issue persist in another user?
IF THE ISSUE IS SYSTEM WIDE
If the issue DOES persist in another user:
Note: It's okay to use the guest user to test to see if the Safari issue is user specific or system wide, however, the troubleshooting should be performed in a new admin account.
First, lets check your plug-ins.
To do this, open Finder, hold down command+shift+g, and a "go to the folder" dialogue box appears. Copy paste:
/library/internet plug-ins
Create a new folder on the desktop, and put any 3rd party add-ons into this.
Restart the computer and try again.
If the issue persists, we may want to look into startup items. To do this, Open Finder, hold down command+shift+g, and a "go to the folder" dialogue box appears. Copy paste:
/library/startupitems
If you have anything here, do the same as we did for the plug-ins, new folder on the desktop, put them there, restart, try again.
If that still doesn't resolve the issue, it may be that Safari itself is broke and needs reinstalled. To do that, we'd need to reinstall the OS (archive & install would work fine).
IF THE ISSUE IS USER SPECIFIC:
If the issue DOESN'T persist in another user, we have a few things to check.
First thing I would do is dump the Safari .plist, caches, and saved application state. To do this, open Finder, hold down command+shift+g, copy and paste in:
~/library/preferences
From here, locate com.apple.safari.plist and drag it into the trash. Immediatly after, hold down command+option+g and copy/paste in:
~/library
Locate your caches folder, drag & drop it into the trash. It will ask for your admin password.
Now, launch Safari with the left shift key held down. Does it still crash?
If yes, I would check user-level plug-ins. To do this, open that "go to the window" menu and copy/paste:
~/library/internet plug-ins
Do the same as for the system level plug ins. New desktop folder, drag/drop them on in.
If the issue still persists...
Login items. Open system preferences, go to users and groups, then choose "login items." If you have stuff in here, disable them.
Restart, try again.
Regards,
Gnomish8

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