How to exclude the manually create SAP PO from MRP Run?

Dear all
There is this situation that due to the long procurement lead time, certain PO is created manually in SAP in advance based on the sales order enquiry made by customer. (In normal case, we will create a sales order in SAP and then run MRP to create PR to converted to PO)
Most of the time, customer will confirm their enquiry so that we can create sales Order in SAP and this will make it just in time for our raw material to arrive. However, when the PO is created in advance without triggered by MRP caused by Sales Order, this PO booked quantity is often taken up by the consideration of MRP RUN by other sales order. And if later customer confirms their enquiry and there is no PO stock for this due to this stock is already considered by other sales order.
Is there a way that I can exclude the manually create SAP PO from MRP Run?
Please advise.

Dear Csaba Szommer
Thanks for your reply.
Sorry for confusing you.
1. We are in a MAKE TO ORDER (MTO) environment.
2. There is this situation that due to the long procurement lead time, certain PO is created manually in SAP in advance based on
    the sales order enquiry made by customer. (In normal case, we will create a sales order in SAP and then run MRP to create
    PR to converted to PO).
3. Most of the time, customer ABCwill confirm their enquiry so that we can create sales Order in SAP and this will make it just in
    time for our raw material to arrive.
4. However, for the PO that is created in advance (not created by PR  triggered by MRP caused by Sales Order), this PO 
    On Order Quantity is often taken up by the consideration of MRP RUN by other sales orders.
5. It creates problem that if later this customer ABC confirms his enquiry and we create SAP Sales Order in the system, the
    stock of PO created previously is already  eaten up by other sales orders.
We are using MTO and do not use Forecast. And MTO Strategy is set at the material master level and as such I do not think we can simply modify the MRP Strategy to suit this unique case, as for the very same material, in one PO it should be considered by MRP but in another PO, it should be excluded from MRP Run.
Is there a way that I can exclude the manually create SAP PO (for the case of Customer ABC email enquiry without creating Sales Order in the System first) from MRP Run?

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