HT201412 A spot on ipad4 does not response

When I type on iPad, there is a spot on iPad does not response whenever I touch on screen or try to type. Any thoughts?

First thing to try is a reboot of your device. Press and hold the Home and Sleep buttons simultaneously ignoring the red slider until the Apple logo appears. Let go of the buttons and let the device restart. See if that fixes your problem.
And it could just be a defective screen. If the reboot didn't help I'd make an appointment at an Apple store for a consultation.

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