I am having a very slow system - from a very fast system

I am suffering from a system that is really slowing down and becoming almost unresponsive some of the time. From a previous post I have learned of EtreCheck and here is the report.
Any help is much appreciated.
Problem description:
slow system
EtreCheck version: 2.0.4 (89)
Report generated 15October, 2014 at 14:43:46 CDT
Hardware Information: ℹ️
  iMac (27-inch, Mid 2011) (Verified)
  iMac - model: iMac12,2
  1 3.4 GHz Intel Core i7 CPU: 4-core
  16 GB RAM Upgradeable
  BANK 0/DIMM0
  4 GB DDR3 1333 MHz ok
  BANK 1/DIMM0
  4 GB DDR3 1333 MHz ok
  BANK 0/DIMM1
  4 GB DDR3 1333 MHz ok
  BANK 1/DIMM1
  4 GB DDR3 1333 MHz ok
  Bluetooth: Old - Handoff/Airdrop2 not supported
  Wireless:  en1: 802.11 a/b/g/n
Video Information: ℹ️
  AMD Radeon HD 6970M - VRAM: 2048 MB
  iMac 2560 x 1440
System Software: ℹ️
  OS X 10.9.5 (13F34) - Uptime: 8 days 8:51:53
Disk Information: ℹ️
  Hitachi HDS722020ALA330 disk0 : (2 TB)
  S.M.A.R.T. Status: Verified
  EFI (disk0s1) <not mounted> : 210 MB
  Macintosh HD (disk0s2) /  [Startup]: 2 TB (2 TB free)
  Recovery HD (disk0s3) <not mounted>  [Recovery]: 650 MB
  HL-DT-STDVDRW  GA32N 
USB Information: ℹ️
  Apple, Inc. Keyboard Hub
  Microsoft Microsoft® USB Hub
  Microsoft Microsoft® Wireless Laser Mouse 8000
  HP Officejet Pro 8500 A910
  Apple Inc. Apple Keyboard
  Apple Inc. BRCM2046 Hub
  Apple Inc. Bluetooth USB Host Controller
  Apple Inc. FaceTime HD Camera (Built-in)
  VIA Labs, Inc.          USB2.0 Hub             
  LaCie Porsche Desktop for Mac 4 TB
  S.M.A.R.T. Status: Verified
  EFI (disk3s1) <not mounted> : 315 MB
  LaCie (disk3s2) /Volumes/LaCie 1 : 4 TB (4 TB free)
  LaCie LaCie Hard Drive USB 2 TB
  S.M.A.R.T. Status: Verified
  disk2s1 (disk2s1) <not mounted> : 32 KB
  LaCie (disk2s3) /Volumes/LaCie : 2 TB (2 TB free)
  STECH    Simple Drive     500.11 GB
  S.M.A.R.T. Status: Verified
  Simple Drive (disk1s1) /Volumes/Simple Drive : 500.11 GB (484.02 GB free)
  Generic USB Ear-Microphone
  Apple Computer, Inc. IR Receiver
  Apple Internal Memory Card Reader
Thunderbolt Information: ℹ️
  Apple Inc. thunderbolt_bus
Gatekeeper: ℹ️
  Mac App Store and identified developers
Kernel Extensions: ℹ️
  /Applications/LaCie Desktop Manager.app
  [not loaded] com.LaCie.ScsiType00 (1.2.13 - SDK 10.5) Support
  [not loaded] com.jmicron.driver.jmPeripheralDevice (2.0.4) Support
  [not loaded] com.lacie.driver.LaCie_RemoteComms (1.0.1 - SDK 10.5) Support
  [not loaded] com.oxsemi.driver.OxsemiDeviceType00 (1.28.13 - SDK 10.5) Support
  /Library/Application Support/MacKeeper/AntiVirus.app
  [loaded] net.kromtech.kext.AVKauth (2.3.7 - SDK 10.9) Support
  [loaded] net.kromtech.kext.Firewall (2.3.7 - SDK 10.9) Support
  /Library/StartupItems/Parallels
  [not loaded] com.parallels.kext.Pvsvnic (3.0) Support
  /Library/StartupItems/VirusBarrier
  [not loaded] com.intego.iokit.VirusBarrierService (1396) Support
  [not loaded] com.intego.kext.VirusBarrier_1694 (10.1.5) Support
  /System/Library/Extensions
  [not loaded] com.Livescribe.iokit.PulseDriver (1.0.0) Support
  [not loaded] com.livescribe.kext.LivescribeSmartpen (1) Support
  [not loaded] com.parallels.kext.ConnectUSB (3.0.0) Support
  [not loaded] com.parallels.kext.Pvsnet (3.0) Support
  [not loaded] com.parallels.kext.hypervisor (3.0) Support
  [not loaded] com.parallels.kext.vmmain (3.0) Support
  [loaded] com.smithMicro.driver.DeviceSentry (5.1) Support
  [loaded] com.smithmicro.DeviceSentryCR (5.1) Support
  [loaded] com.smithmicro.nke.NetBlockade (5.1) Support
  [loaded] com.smithmicro.nke.NetworkSpyAlert (5.1) Support
  [not loaded] net.telestream.driver.IODVDImage (1.0 ) Support
  /System/Library/Extensions/DeviceSentry.kext/Contents/PlugIns
  [not loaded] com.smithMicro.driver.DeviceSentryBD (5.1) Support
  [not loaded] com.smithMicro.driver.DeviceSentryCD (5.1) Support
  [loaded] com.smithMicro.driver.DeviceSentryDVD (5.1) Support
Startup Items: ℹ️
  comapcpcpestart: Path: /Library/StartupItems/comapcpcpestart
  esets_daemon_si: Path: /Library/StartupItems/esets_daemon_si
  HP IO: Path: /Library/StartupItems/HP IO
  Macaroni: Path: /Library/StartupItems/Macaroni
  Parallels: Path: /Library/StartupItems/Parallels
  ParallelsTransporter: Path: /Library/StartupItems/ParallelsTransporter
  VirusBarrier: Path: /Library/StartupItems/VirusBarrier
  WDMyBookServiceStartupItem: Path: /Library/StartupItems/WDMyBookServiceStartupItem
  Startup items are obsolete and will not work in future versions of OS X
Problem System Launch Daemons: ℹ️
  [failed] com.apple.AOSNotificationOSX.plist
  [failed] com.apple.wdhelper.plist
Launch Agents: ℹ️
  [not loaded] com.adobe.AAM.Updater-1.0.plist Support
  [invalid?] com.brother.LOGINserver.plist Support
  [loaded] com.carbonite.launchd.carbonitealerts.plist Support
  [running] com.carbonite.launchd.carbonitestatus.plist Support
  [loaded] com.google.keystone.agent.plist Support
  [loaded] com.hp.help.tocgenerator.plist Support
  [running] com.hp.productresearch.plist Support
  [loaded] com.intego.backupassistant.agent.plist Support
  [running] com.intego.commonservices.integomenu.plist Support
  [loaded] com.intego.commonservices.taskmanager.plist Support
  [loaded] com.intego.commonservices.uninstaller.plist Support
  [running] com.intego.netupdate.agent.plist Support
  [loaded] com.oracle.java.Java-Updater.plist Support
  [running] com.pegatech.NoteTakerService.plist Support
  [running] com.smithmicro.SmithMicroPGGAgent.plist Support
Launch Daemons: ℹ️
  [loaded] com.adobe.fpsaud.plist Support
  [invalid?] com.backblaze.bzserv.plist Support
  [running] com.carbonite.launchd.carbonitedaemon.plist Support
  [failed] com.crashplan.engine.plist Support
  [running] com.distortedvista.istatmenusprocessserver.plist Support
  [failed] com.google.GoogleML.plist Support
  [loaded] com.google.keystone.daemon.plist Support
  [running] com.intego.BackupAssistant.daemon.plist Support
  [running] com.intego.commonservices.daemon.integod.plist Support
  [running] com.intego.commonservices.daemon.taskmanager.plist Support
  [loaded] com.intego.commonservices.icalserver.plist Support
  [loaded] com.intego.commonservices.metrics.kschecker.plist Support
  [running] com.intego.netupdate.daemon.plist Support
  [failed] com.livescribe.PenCommService.plist Support
  [loaded] com.microsoft.office.licensing.helper.plist Support
  [loaded] com.oracle.java.Helper-Tool.plist Support
  [loaded] com.oracle.java.JavaUpdateHelper.plist Support
  [loaded] com.prosofteng.DriveGenius.locum.plist Support
  [running] com.prosoftnet.idrivedaemon.plist Support
  [running] com.prosoftnet.idsyncdaemon.plist Support
  [running] com.prosoftnet.idwebdaemon.plist Support
  [loaded] com.sharpcast.xfsmond.plist Support
  [running] com.smithmicro.schedulerdaemon.plist Support
  [invalid?] com.smithmicro.smithmicropggd.plist Support
  [loaded] com.stclairsoft.DefaultFolderXAgent.plist Support
  [running] com.zeobit.MacKeeper.AntiVirus.plist Support
  [running] com.zeobit.MacKeeper.plugin.AntiTheft.daemon.plist Support
  [failed] openbase.plist Support
User Launch Agents:

Here's where I am now:
Problem description:
slow system 16Oct2014_1153
EtreCheck version: 2.0.4 (89)
Report generated 16October, 2014 at 11:53:28 CDT
Hardware Information: ℹ️
         iMac (27-inch, Mid 2011) (Verified)
         iMac - model: iMac12,2
         1 3.4 GHz Intel Core i7 CPU: 4-core
         16 GB RAM Upgradeable
                   BANK 0/DIMM0
                            4 GB DDR3 1333 MHz ok
                   BANK 1/DIMM0
                            4 GB DDR3 1333 MHz ok
                   BANK 0/DIMM1
                            4 GB DDR3 1333 MHz ok
                   BANK 1/DIMM1
                            4 GB DDR3 1333 MHz ok
         Bluetooth: Old - Handoff/Airdrop2 not supported
         Wireless:  en1: 802.11 a/b/g/n
Video Information: ℹ️
         AMD Radeon HD 6970M - VRAM: 2048 MB
                   iMac 2560 x 1440
System Software: ℹ️
         OS X 10.9.5 (13F34) - Uptime: 4:51:16
Disk Information: ℹ️
         Hitachi HDS722020ALA330 disk0 : (2 TB)
         S.M.A.R.T. Status: Verified
                   EFI (disk0s1) <not mounted> : 210 MB
              Macintosh HD (disk0s2) /  [Startup]: 2 TB (2 TB free)
                   Recovery HD (disk0s3) <not mounted> [Recovery]: 650 MB
         HL-DT-STDVDRW  GA32N 
USB Information: ℹ️
         Apple Inc. FaceTime HD Camera (Built-in)
         Apple, Inc. Keyboard Hub
                   Microsoft Microsoft® USB Hub
                            Microsoft Microsoft® Wireless Laser Mouse 8000
                   HP Officejet Pro 8500 A910
                   Apple Inc. Apple Keyboard
         Apple Inc. BRCM2046 Hub
                   Apple Inc. Bluetooth USB Host Controller
         VIA Labs, Inc.          USB2.0 Hub             
                   LaCie Porsche Desktop for Mac 4 TB
                            S.M.A.R.T. Status: Verified
                            EFI (disk2s1) <not mounted> : 315 MB
                            LaCie (disk2s2) /Volumes/LaCie : 4 TB (4 TB free)
                   LaCie LaCie Hard Drive USB 2 TB
                            S.M.A.R.T. Status: Verified
                            disk3s1 (disk3s1) <not mounted> : 32 KB
                            LaCie (disk3s3) /Volumes/LaCie 1 : 2 TB (2 TB free)
                   STECH    Simple Drive     500.11 GB
                            S.M.A.R.T. Status: Verified
                            Simple Drive (disk1s1) /Volumes/Simple Drive : 500.11 GB (484.02 GB free)
                   Generic USB Ear-Microphone
         Apple Computer, Inc. IR Receiver
         Apple Internal Memory Card Reader
Thunderbolt Information: ℹ️
         Apple Inc. thunderbolt_bus
Gatekeeper: ℹ️
         Mac App Store and identified developers
Kernel Extensions: ℹ️
                            /Applications/LaCie Desktop Manager.app
         [not loaded]        com.LaCie.ScsiType00 (1.2.13 - SDK 10.5) Support
         [not loaded]        com.jmicron.driver.jmPeripheralDevice (2.0.4) Support
         [not loaded]        com.lacie.driver.LaCie_RemoteComms (1.0.1 - SDK 10.5) Support
         [not loaded]        com.oxsemi.driver.OxsemiDeviceType00 (1.28.13 - SDK 10.5) Support
                            /Library/StartupItems/Parallels
         [not loaded]        com.parallels.kext.Pvsvnic (3.0) Support
                            /System/Library/Extensions
         [not loaded]        com.Livescribe.iokit.PulseDriver (1.0.0) Support
         [not loaded]        com.livescribe.kext.LivescribeSmartpen (1) Support
         [not loaded]        com.parallels.kext.ConnectUSB (3.0.0) Support
         [not loaded]        com.parallels.kext.Pvsnet (3.0) Support
         [not loaded]        com.parallels.kext.hypervisor (3.0) Support
         [not loaded]        com.parallels.kext.vmmain (3.0) Support
         [loaded]              com.smithMicro.driver.DeviceSentry (5.1) Support
         [loaded]              com.smithmicro.DeviceSentryCR (5.1) Support
         [loaded]              com.smithmicro.nke.NetBlockade (5.1) Support
         [not loaded]        net.telestream.driver.IODVDImage (1.0 ) Support
                            /System/Library/Extensions/DeviceSentry.kext/Contents/PlugIns
         [not loaded]        com.smithMicro.driver.DeviceSentryBD (5.1) Support
         [not loaded]        com.smithMicro.driver.DeviceSentryCD (5.1) Support
         [loaded]              com.smithMicro.driver.DeviceSentryDVD (5.1) Support
Startup Items: ℹ️
         comapcpcpestart: Path: /Library/StartupItems/comapcpcpestart
         esets_daemon_si: Path: /Library/StartupItems/esets_daemon_si
         HP IO: Path: /Library/StartupItems/HP IO
         Macaroni: Path: /Library/StartupItems/Macaroni
         Parallels: Path: /Library/StartupItems/Parallels
         ParallelsTransporter: Path: /Library/StartupItems/ParallelsTransporter
         WDMyBookServiceStartupItem: Path: /Library/StartupItems/WDMyBookServiceStartupItem
         Startup items are obsolete and will not work in future versions of OS X
Launch Agents: ℹ️
         [not loaded]        com.adobe.AAM.Updater-1.0.plist Support
         [loaded]              com.carbonite.launchd.carbonitealerts.plist Support
         [running]              com.carbonite.launchd.carbonitestatus.plist Support
         [loaded]              com.google.keystone.agent.plist Support
         [loaded]              com.hp.help.tocgenerator.plist Support
         [running]              com.hp.productresearch.plist Support
         [loaded]              com.oracle.java.Java-Updater.plist Support
         [running]              com.pegatech.NoteTakerService.plist Support
         [running]              com.smithmicro.SmithMicroPGGAgent.plist Support
Launch Daemons: ℹ️
         [loaded]              com.adobe.fpsaud.plist Support
         [invalid?]             com.backblaze.bzserv.plist Support
         [running]              com.carbonite.launchd.carbonitedaemon.plist Support
         [running]              com.distortedvista.istatmenusprocessserver.plist Support
         [failed]                 com.google.GoogleML.plist Support
         [loaded]              com.google.keystone.daemon.plist Support
         [failed]                 com.livescribe.PenCommService.plist Support
         [loaded]              com.microsoft.office.licensing.helper.plist Support
         [loaded]              com.oracle.java.Helper-Tool.plist Support
         [loaded]              com.oracle.java.JavaUpdateHelper.plist Support
         [running]              com.prosoftnet.idrivedaemon.plist Support
         [running]              com.prosoftnet.idsyncdaemon.plist Support
         [running]              com.prosoftnet.idwebdaemon.plist Support
         [loaded]              com.sharpcast.xfsmond.plist Support
         [loaded]              com.stclairsoft.DefaultFolderXAgent.plist Support
         [failed]                 openbase.plist Support
User Launch Agents: ℹ️
         [loaded]              com.adobe.ARM.[...].plist Support
         [running]              com.akamai.single-user-client.plist Support
         [loaded]              com.chronos.CHBackupAgent.plist Support
         [running]              com.ecamm.printopia.plist Support
         [invalid?]             com.google.Chrome.framework.plist Support
         [invalid?]             com.leadertech.PowerRegister.FUJ1.9e185efee63d7548c264550bd3f7af3f.plist Support
         [loaded]              com.logos.LogosIndexer.plist Support
         [running]              com.microsoft.LaunchAgent.SyncServicesAgent.plist Support
         [running]              com.smithmicro.cleaning.schedulermailer.plist Support
         [invalid?]             com.zimbra.desktop.plist Support
         [invalid?]             com.zimbra.zdesktop.plist Support
         [running]              ws.agile.1PasswordAgent.plist Support
User Login Items: ℹ️
         System Events Application (/System/Library/CoreServices/System Events.app)
         Default Folder X Helper               Application (/Library/PreferencePanes/Default Folder X.prefPane/Contents/Resources/Default Folder X Helper.app)
         Default Folder X                            Application (/Library/PreferencePanes/Default Folder X.prefPane/Contents/Resources/Default Folder X.app)
         Dropbox            Application (/Applications/Dropbox.app)
         Copy                 UNKNOWNHidden (missing value)
         PopChar            ApplicationHidden (/Applications/PopChar.app)
         Fantastical           Application (/Applications/Fantastical.app)
         Box Sync           ApplicationHidden (/Applications/Box Sync.app)
         NoteBookHelper                          Application (/Users/[redacted]/Library/Services/NoteBookHelper.service)
         SOHOCalendarsService            UNKNOWN (missing value)
         MailTagsHelper                            Application (/Users/[redacted]/Library/Application Support/Indev/MailTagsHelper.app)
         DEVONthink Sorter                      Application (/Applications/DEVONthink Pro.app/Contents/PlugIns/SorterPlugin.bundle/Contents/MacOS/DEVONthink Sorter.app)
         HP Product Research                   ApplicationHidden (/Library/Application Support/Hewlett-Packard/Customer Participation/HP Product Research.app)
Internet Plug-ins: ℹ️
         nplastpass: Version: 2.5.5 Support
         o1dbrowserplugin: Version: 5.4.2.18903 Support
         Google Earth Web Plug-in: Version: 6.0 Support
         Default Browser: Version: 537 - SDK 10.9
         Flip4Mac WMV Plugin: Version: 3.2.0.16   - SDK 10.8 Support
         OfficeLiveBrowserPlugin: Version: 12.2.7 Support
         RealPlayer Plugin: Version: (null) Support
         AdobeAAMDetect: Version: AdobeAAMDetect 1.0.0.0 - SDK 10.6 Support
         FlashPlayer-10.6: Version: 15.0.0.152 - SDK 10.6 Support
         AdobePDFViewerNPAPI: Version: 11.0.09 - SDK 10.6 Support
         Silverlight: Version: 5.1.30514.0 - SDK 10.6 Support
         Flash Player: Version: 15.0.0.152 - SDK 10.6 Mismatch! Adobe recommends 15.0.0.189
         iPhotoPhotocast: Version: 7.0
         googletalkbrowserplugin: Version: 5.4.2.18903 Support
         QuickTime Plugin: Version: 7.7.3
         AdobePDFViewer: Version: 11.0.09 - SDK 10.6 Support
         SharePointBrowserPlugin: Version: 14.4.5 - SDK 10.6 Support
         Unity Web Player: Version: UnityPlayer version 2.6.1f3 Support
         JavaAppletPlugin: Version: Java 7 Update 67 Check version
User Internet Plug-ins: ℹ️
         Picasa: Version: 1.0 Support
         Google Earth Web Plug-in: Version: 7.0 Support
Safari Extensions: ℹ️
         markerto
         Instapaper Article Tools (Disabled)
         Add To Amazon Wish List (Disabled)
         Evernote Web Clipper
         DuckDuckGo
         AdBlock
         Ticker
         Translate
         Shortly
         Clip to DEVONthink
         LastPass
         AllPagesZoom
3rd Party Preference Panes: ℹ️
         Akamai NetSession Preferences  Support
         APC PowerChute Personal Edition  Support
         Carbonite  Support
         Default Folder X  Support
         Flash Player  Support
         Flip4Mac WMV  Support
         FUSE for OS X (OSXFUSE)  Support
         iStat menus  Support
         Java  Support
         Macaroni  Support
         OpenBasePreferences  Support
         Printopia  Support
         Xmarks for Safari  Support
Time Machine: ℹ️
         Skip System Files: NO
         Mobile backups: OFF
         Auto backup: YES
         Volumes being backed up:
                   Macintosh HD: Disk size: 2 TB Disk used: 157.37 GB
         Destinations:
                   LaCie [Local]
                   Total size: 4 TB
                   Total number of backups: 60
                   Oldest backup: 2014-07-14 20:42:21 +0000
                   Last backup: 2014-10-16 15:58:59 +0000
                   Size of backup disk: Adequate
                            Backup size 4 TB > (Disk used 157.37 GB X 3)
Top Processes by CPU: ℹ️
             52%      softwareupdated
              3%        WindowServer
              0%        Finder
              0%        Hour Lite
              0%        sysmond
Top Processes by Memory: ℹ️
         653 MB             mds_stores
         636 MB             Finder
         533 MB             Mail
         361 MB             Safari
         344 MB             com.apple.IconServicesAgent
Virtual Memory Information: ℹ️
         7.81 GB             Free RAM
         5.74 GB             Active RAM
         1.97 GB             Inactive RAM
         1.66 GB             Wired RAM
         1.39 GB             Page-ins
         0 B                      Page-outs

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