I am having awful problems with mouse and trackpad after installing Lion

I have tried 3 different brands of mice and it happens with each one. the mouse clicks and sticks spontaniously and wont let go and hitting esc or trying to click somewhere else doesn't have any effect - it wont let go. And it doesn't seem to matter which program. At forst i thought it was just pwer point but it still happens if I command/tab over to mail or finder. and then I get the stupid wheel of death. power point (or whatever program I'm in) locks up. and then I lose recent edits.
I have a Mac book pro. I have use and external keyboard and monitor when I'm at my office.
When the problem has happened I have tried using the trackpad - but it's like it's dead. No click effect. No help!
I AM REALLY TRYING TO NOT GET ANGRY - BUT I AM READY TO SCRAP LION!!!!!!!!!!!
HELP!!!!!!!!

Thanks for the tip re MagicPrefs! Great app!
Is anyone having trouble with Mac losing the connection to Magic Mouse after the Mac goes to sleep? I am running Mac Mini late 2009 with dual-core 2.0 GHz and 4 GB RAM. Never had any issues under Snow Leopard, only after the upgrade to Lion. Battery is OK (tried fresh ones with no luck).
Turning the mouse off then on does not help, but ocasionally I have been able to get the mouse back by simply using Command+Tab. It does not seem to matter which app is active.

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