I am having issues with certain applications just not starting up..

This is my first post here..
Thanks in advance for any help available!
A few of my apps have stoped working such as: iTunes, Safari, Skype, my mail box and its really frustrating. I just DL'd firefox and have been using this and today I tried deleting all of the itunes apps and files and tried dl'ing a new one from itunes.com
Its weird, down at my toolbar, when I click on an icon it bounces once and then nothing else happens.
I dont know if my hardrive is damaged or what, but I am unable to re-download the new itunes.
Has anyone had this probles? Could it possibly be a virus? And help is very much appreciated because I REALLY dont want to purchase a new computer.
thanks,
J

when I clicked the verify disc icon it stated:
Verifying volume “Macintosh HD”
Checking HFS Plus volume.
Checking Extents Overflow file.
Checking Catalog file.
Missing thread record (id = 9638)
Missing thread record (id = 9641)
Missing thread record (id = 9644)
Missing thread record (id = 9647)
Missing thread record (id = 9650)
Missing thread record (id = 9653)
Invalid index key
The volume Macintosh HD needs to be repaired.
Error: The underlying task reported failure on exit
1 HFS volume checked
Volume needs repair

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