I AM USING SAFARI 5.1.10.  Cannot quit safari application.  Quit option is "grayed out" on menu.

Cannot quit safari 5.1.10.  Quit option is grayed out on the menu.  Any idea why this happening?

Press Command + Option + Esc on your keyboard to force quit Safari.
If that doesn't work, use the Activity Monitor as noted here >  OS X: How to quit an unresponsive application using Force Quit
It may be due to malware, or incompatible Safari extensions or plug-ins.

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