I can not open photoshop?!

Error message says my "preference file is invalid-- it has been deleted." Any thoughts? I'm anxious because I need to send my material to a printer today!

1st option - Try a keystroke reset: open photoshop while holding down Ctrl + Alt + Shift (Windows) or Command + Option + Shift, which should prompt up a reset dialog (you might have to run Photoshop as administrator in certain instances).
2nd option - Delete your preferences folder (Preference file functions, names, locations | Photoshop CS5)

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