I can't launch any downloaded applications!!! Don't ask for permission

Normally/Before, when i download an app, i click to open, it will pop up a windows to ask me if i want to open it, for it's downloaded from the internet, i will allow it.
But now, nothing pop up, and if i launch no matter which app downloaded from the net, the icon in the dock keep jumping and nothing happen.
I think its certain a problem of permission. Here is what i have done:
I repaired the disk permission;
I installed the latest system and java update(though i don't know if its relevent);
Check the file permission.
I show the contents of the app package, i try to launch the "XXXX XXXXX" file directly under the file "MacOS". So it's terminal, says:
Last login: Tue May 8 16:48:59 on console
DXMB:~ DX$ /Volumes/ XXXXX\ XXXXX.app/Contents/MacOS/XXXX\XXXXXXX ; exit;
-bash: /Volumes/XXXX XXXXX/XXXX XXXXX.app/Contents/MacOS/XXXX XXXXX: Operation not permitted
logout
[Opération terminée]
I suppose the problem is simple, there is no longer the pop up window to ask for permission?
What can i do?! I searched on the net, but found nothing.....
Thanks!

Thank u baltwo, I know a reinstallation will work out, but i really don't want to, so i come here to see your opinions
Just a reinstall without erase my contents seems not impossible? and won't work?

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I can't launch any downloaded applications!!! Don't ask for permission

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