I can't open any app on my mac, they just flicker on the dock and nothing

I'm using MacBook Pro 13in Early 2011 and recent update to Mavericks, I cant open any application on my mac. There is an updates on app store but I can't use them cause the app store refuse to open. When I open any apps they just flicker on the dock and nothing. What to do apart from formating my computor again?

Have you tried a Safe Boot?
Allan

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