I can't open anything on my desktop, can't right click either. Please help

I hope that someone will have a simple solution to my problem. I need you to speak to me like a 10 yr old about this computer!!  To start out I found the computer screen locked on my daughters FB page. The mouse works, but the computer won't  let you click on anything. I had to manually turn computer off and restarted. My desktop comes up, however I can not open anything! And my Safari Icon is gone, and the firefox icon that I use for work purposes, has changed to a question mark. Please let me know how to procede!!

More details, please.  Did you simply install Lion over the top of the Snow Leopard installation that was already on your Mac, or did you do something else?
How are you trying to open those things?  What happens when you try?
Can you select anything on the Desktop?  If you do that and invoke the menu option File > Get Info, what's the first thing you see under "Name" in the "Sharing & Permissions" section of the resulting window?

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