I can't open itunes message says you dont have the appropiate permission to acces the item

i update itunes to the new update an appear a message saying  windows cannot acces the specified ,device,path or file you may not have the appropiate permission to acces the iten how can a fix it y desinstall itunes  and install it two times and still not working

Make sure that you have closed all programs that might be using the iTunes library.itl file. I would hit CTRL + ALT + DEL buttons and enter the Task Manager - from there end any unnecessary program running in the background.
Next try to start iTunes again. If it fails, restart PC, do the same with Task Manager and try to open iTunes again.

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    26/09/13 10:11:17.946 PM com.apple.launchd: (com.sophos.intercheck) Throttling respawn: Will start in 10 seconds
    26/09/13 10:11:17.946 PM com.apple.launchd: (com.sophos.autoupdate[6461]) Exited with code: 1
    26/09/13 10:11:17.946 PM com.apple.launchd: (com.sophos.autoupdate) Throttling respawn: Will start in 10 seconds
    26/09/13 10:11:17.946 PM com.apple.launchd: (com.sophos.notification[6462]) Exited with code: 1
    26/09/13 10:11:17.946 PM com.apple.launchd: (com.sophos.notification) Throttling respawn: Will start in 10 seconds
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    26/09/13 10:11:22.617 PM Safari: self <TabContentView: 0x7f8d5db7bb00>
    26/09/13 10:11:27.866 PM Safari: self <TabContentView: 0x7f8d5c331a70>
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    Wed Sep 25 15:39:39 2013
    panic(cpu 0 caller 0xffffff80002c4794): Kernel trap at 0xffffff7f81757965, type 14=page fault, registers:
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    RAX: 0x000000001d31a000, RBX: 0x0000000000000000, RCX: 0x0000000000000000, RDX: 0x0000000000000000
    RSP: 0xffffff80b0dbb710, RBP: 0xffffff80b0dbb820, RSI: 0x0000000000000000, RDI: 0x0000000000000001
    R8:  0x000000000000000a, R9:  0x0000000000000378, R10: 0x0000000000000128, R11: 0x0000000000000378
    R12: 0xffffff800c626400, R13: 0x0000000000000000, R14: 0x0000000000000000, R15: 0xffffff81acc39802
    RFL: 0x0000000000010246, RIP: 0xffffff7f81757965, CS:  0x0000000000000008, SS:  0x0000000000000010
    CR2: 0xffffff81acc397fe, Error code: 0x0000000000000000, Faulting CPU: 0x0
    Backtrace (CPU 0), Frame : Return Address
    0xffffff80b0dbb3c0 : 0xffffff8000220792
    0xffffff80b0dbb440 : 0xffffff80002c4794
    0xffffff80b0dbb5f0 : 0xffffff80002da55d
    0xffffff80b0dbb610 : 0xffffff7f81757965
    0xffffff80b0dbb820 : 0xffffff7f817667a0
    0xffffff80b0dbb840 : 0xffffff7f8173a58e
    0xffffff80b0dbb870 : 0xffffff7f8177fb6f
    0xffffff80b0dbb8a0 : 0xffffff7f81779632
    0xffffff80b0dbb8d0 : 0xffffff7f8177d7d5
    0xffffff80b0dbb900 : 0xffffff7f8177c6db
    0xffffff80b0dbb9e0 : 0xffffff7f817412b8
    0xffffff80b0dbba10 : 0xffffff7f81778684
    0xffffff80b0dbba30 : 0xffffff7f817449ce
    0xffffff80b0dbbb60 : 0xffffff7f81741a4c
    0xffffff80b0dbbbc0 : 0xffffff8000655f3e
    0xffffff80b0dbbbe0 : 0xffffff800065681a
    0xffffff80b0dbbc40 : 0xffffff8000656fbb
    0xffffff80b0dbbd80 : 0xffffff80002a3f08
    0xffffff80b0dbbe80 : 0xffffff8000223096
    0xffffff80b0dbbeb0 : 0xffffff80002148a9
    0xffffff80b0dbbf10 : 0xffffff800021bbd8
    0xffffff80b0dbbf70 : 0xffffff80002aef10
    0xffffff80b0dbbfb0 : 0xffffff80002daec3
          Kernel Extensions in backtrace:
             com.apple.driver.AppleIntelHD3000Graphics(7.3.2)[A2328231-E577-32FF-B20F-D08BDC FE9C51]@0xffffff7f81738000->0xffffff7f8179bfff
                dependency: com.apple.iokit.IOPCIFamily(2.7)[5C23D598-58B2-3204-BC03-BC3C0F00BD32]@0xffffff 7f80889000
                dependency: com.apple.iokit.IONDRVSupport(2.3.4)[7C8672C4-8B0D-3CCF-A79A-23C62E90F895]@0xff ffff7f80d2e000
                dependency: com.apple.iokit.IOGraphicsFamily(2.3.4)[D0A1F6BD-E66E-3DD8-9913-A3AB8746F422]@0 xffffff7f80cf5000
    BSD process name corresponding to current thread: WindowServer
    Mac OS version:
    11G63b
    Kernel version:
    Darwin Kernel Version 11.4.2: Thu Aug 23 16:25:48 PDT 2012; root:xnu-1699.32.7~1/RELEASE_X86_64
    Kernel UUID: FF3BB088-60A4-349C-92EA-CA649C698CE5
    System model name: MacBookPro8,1 (Mac-94245B3640C91C81)
    System uptime in nanoseconds: 1866666823698
    last loaded kext at 480357661446: com.apple.filesystems.smbfs          1.7.2 (addr 0xffffff7f80795000, size 241664)
    last unloaded kext at 303348424187: com.apple.driver.AppleUSBUHCI          5.1.0 (addr 0xffffff7f80af7000, size 65536)
    loaded kexts:
    com.sophos.kext.sav          8.0.14
    org.virtualbox.kext.VBoxNetAdp          4.2.16
    org.virtualbox.kext.VBoxNetFlt          4.2.16
    org.virtualbox.kext.VBoxUSB          4.2.16
    org.virtualbox.kext.VBoxDrv          4.2.16
    com.logmein.driver.LogMeInSoundDriver          1.0.2
    com.Greatdy.driver.SystemAudioCapture          1.0.0
    com.apple.filesystems.smbfs          1.7.2
    com.apple.driver.AppleHWSensor          1.9.5d0
    com.apple.driver.AppleMikeyHIDDriver          122
    com.apple.iokit.IOBluetoothSerialManager          4.0.8f17
    com.apple.driver.AudioAUUC          1.59
    com.apple.driver.AppleHDA          2.2.5a5
    com.apple.driver.AppleMikeyDriver          2.2.5a5
    com.apple.driver.AGPM          100.12.75
    com.apple.driver.AppleUpstreamUserClient          3.5.9
    com.apple.driver.SMCMotionSensor          3.0.2d6
    com.apple.driver.AppleSMCPDRC          5.0.0d8
    com.apple.iokit.IOUserEthernet          1.0.0d1
    com.apple.Dont_Steal_Mac_OS_X          7.0.0
    com.apple.driver.AudioIPCDriver          1.2.3
    com.apple.driver.AppleSMCLMU          2.0.1d2
    com.apple.driver.ApplePolicyControl          3.1.33
    com.apple.driver.ACPI_SMC_PlatformPlugin          5.0.0d8
    com.apple.driver.AppleIntelHD3000Graphics          7.3.2
    com.apple.driver.AppleBacklight          170.2.2
    com.apple.driver.AppleLPC          1.6.0
    com.apple.driver.AppleMCCSControl          1.0.33
    com.apple.filesystems.autofs          3.0
    com.apple.driver.AppleUSBTCButtons          227.6
    com.apple.driver.BroadcomUSBBluetoothHCIController          4.0.8f17
    com.apple.driver.AppleUSBTCKeyboard          227.6
    com.apple.driver.AppleIRController          312
    com.apple.AppleFSCompression.AppleFSCompressionTypeDataless          1.0.0d1
    com.apple.AppleFSCompression.AppleFSCompressionTypeZlib          1.0.0d1
    com.apple.BootCache          33
    com.apple.iokit.SCSITaskUserClient          3.2.1
    com.apple.driver.XsanFilter          404
    com.apple.iokit.IOAHCISerialATAPI          2.0.3
    com.apple.iokit.IOAHCIBlockStorage          2.1.0
    com.apple.driver.AppleUSBHub          5.1.0
    com.apple.driver.AppleFWOHCI          4.9.0
    com.apple.driver.AirPort.Brcm4331          561.7.22
    com.apple.driver.AppleSDXC          1.2.2
    com.apple.iokit.AppleBCM5701Ethernet          3.2.4b8
    com.apple.driver.AppleEFINVRAM          1.6.1
    com.apple.driver.AppleSmartBatteryManager          161.0.0
    com.apple.driver.AppleAHCIPort          2.3.1
    com.apple.driver.AppleUSBEHCI          5.1.0
    com.apple.driver.AppleACPIButtons          1.5
    com.apple.driver.AppleRTC          1.5
    com.apple.driver.AppleHPET          1.7
    com.apple.driver.AppleSMBIOS          1.9
    com.apple.driver.AppleACPIEC          1.5
    com.apple.driver.AppleAPIC          1.6
    com.apple.driver.AppleIntelCPUPowerManagementClient          195.0.0
    com.apple.nke.applicationfirewall          3.2.30
    com.apple.security.quarantine          1.4
    com.apple.security.TMSafetyNet          8
    com.apple.driver.AppleIntelCPUPowerManagement          195.0.0
    com.apple.iokit.IOSerialFamily          10.0.5
    com.apple.driver.DspFuncLib          2.2.5a5
    com.apple.iokit.IOSurface          80.0.2
    com.apple.iokit.IOFireWireIP          2.2.5
    com.apple.driver.AppleHDAController          2.2.5a5
    com.apple.iokit.IOHDAFamily          2.2.5a5
    com.apple.iokit.IOAudioFamily          1.8.6fc18
    com.apple.kext.OSvKernDSPLib          1.3
    com.apple.driver.AppleGraphicsControl          3.1.33
    com.apple.driver.AppleSMC          3.1.3d10
    com.apple.driver.IOPlatformPluginLegacy          5.0.0d8
    com.apple.driver.AppleSMBusPCI          1.0.10d0
    com.apple.driver.AppleBacklightExpert          1.0.4
    com.apple.driver.IOPlatformPluginFamily          5.1.1d6
    com.apple.iokit.IONDRVSupport          2.3.4
    com.apple.driver.AppleSMBusController          1.0.10d0
    com.apple.driver.AppleIntelSNBGraphicsFB          7.3.2
    com.apple.iokit.IOGraphicsFamily          2.3.4
    com.apple.kext.triggers          1.0
    com.apple.driver.AppleUSBBluetoothHCIController          4.0.8f17
    com.apple.iokit.IOBluetoothFamily          4.0.8f17
    com.apple.driver.AppleThunderboltDPInAdapter          1.8.5
    com.apple.driver.AppleThunderboltDPAdapterFamily          1.8.5
    com.apple.driver.AppleThunderboltPCIDownAdapter          1.2.5
    com.apple.driver.AppleUSBMultitouch          230.5
    com.apple.iokit.IOUSBHIDDriver          5.0.0
    com.apple.driver.AppleUSBMergeNub          5.1.0
    com.apple.driver.AppleUSBComposite          5.0.0
    com.apple.iokit.IOSCSIMultimediaCommandsDevice          3.2.1
    com.apple.iokit.IOBDStorageFamily          1.7
    com.apple.iokit.IODVDStorageFamily          1.7.1
    com.apple.iokit.IOCDStorageFamily          1.7.1
    com.apple.iokit.IOSCSIArchitectureModelFamily          3.2.1
    com.apple.driver.AppleThunderboltNHI          1.6.0
    com.apple.iokit.IOThunderboltFamily          2.0.3
    com.apple.iokit.IOUSBUserClient          5.0.0
    com.apple.iokit.IOFireWireFamily          4.4.8
    com.apple.iokit.IO80211Family          420.3
    com.apple.iokit.IOEthernetAVBController          1.0.1b1
    com.apple.iokit.IONetworkingFamily          2.1
    com.apple.iokit.IOAHCIFamily          2.0.8
    com.apple.iokit.IOUSBFamily          5.1.0
    com.apple.driver.AppleEFIRuntime          1.6.1
    com.apple.iokit.IOHIDFamily          1.7.1
    com.apple.iokit.IOSMBusFamily          1.1
    com.apple.security.sandbox          177.11
    com.apple.kext.AppleMatch          1.0.0d1
    com.apple.driver.DiskImages          331.7
    com.apple.iokit.IOStorageFamily          1.7.2
    com.apple.driver.AppleKeyStore          28.18
    com.apple.driver.AppleACPIPlatform          1.5
    com.apple.iokit.IOPCIFamily          2.7
    com.apple.iokit.IOACPIFamily          1.4

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