I can't open LR5 or Adobe reader please help!

I just tried to open the two and they both won't work. Please help.
I am running the newest versions of OS X and LR
Thank you in advance.

Unfortunately, the most likely cause is due to the Office update as the only known change that occurred just before Lr stopped responding, and it may have corrupted Lr.
If you can't get it to start after trying more things, perhaps you should try uninstalling and reinstalling it as a last resort, an action that may seem daunting now, but that many have done to solve this sort of problem. It's worth mentioning that doing does not affect any presets or your catalog.
Of course, you always have current backups to fall back on, don't you, if you decide to go down the above route?

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