I can't open Mail at all on my iMac.

Hi,I can't open Mail at all on my iMac,I'm running Mountain Lion 10.8.3.This has been happening a few times since I did the last system update but now it's completely gone.The Mail icon is there in the dock and in Applications but nothing happens when I click on it.I'd appreciate if anyone has any ideas.Thank you.

If you haven't already, try re-applying the update using the combo. It sometimes helps solve odd problems:
http://support.apple.com/kb/DL1640

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