I can't save changes to my PDF document?

I downloaded a PDF document from Google Chrome onto my desktop. (It's a job application). However, every time I make changes to it, click save, and then open it up again using Preview, none of my changes have saved. Help?

No -- I installed adobe acrobat -- and now, whether I'm signed in or not -- the little disc/save icon is whited out and it can no longer be selected -- when I open a PDF I can only save it to the cloud
I am a physician, and a lot of what I look at is protected health information --- I can't be saving it in the cloud!!!  I have to find a way to disable this feature -- and restore my ability to save to my hard drive ONLY --
Thanks -- but if you can tell me those things, I'll be grateful
tried to attach screen shot to show you, but it was too big .......

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