I cannot open InDesign files after upgrading to CS6.

Error message is "Cannot open the file *.indd. Adobe InDesign may not support the file format, a plug in that support the file format, a plug-in that supports the file format may be missing, or the file may be open in another application" Can anyone help!

That message means exactly what it says, more or less. The three possibilities are it isn't an InDesign file at all (we see that here a lot), there is a .idlk lock file in the same folder (delete it), or the file has been damaged (frequently happens with flash drives).
If you open the file in a plain text editor like NotePad or TextEdit (it will look like gibberish) and paste the first few lines here we may be able to tell you if the file is damaged or not an InDesign file.

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