I cant save a pdf after editing

I cant save a pdf after editing it. My edits = mark up of text using yellow highlight marker.
the file downloaded from internet by doing saving as (in explorer that opened the pdf once cliced upon in the browser)
the file looks like an pdf in my organizer
use acrobat 9 pro
browers explorer 9
system windows 9 enterprise

I have the same problem. I have a PDF thats 1gb, and it hasnt been any problems saving it in the past, but now when i try to add other pdf-documents to it i cant save the file. Literally nothing happens when i press "save", or "save as".
I have tried to make a copy of the file and that doesnt help. Everything is "Allowed" when i check ctrl+d.
What can be wrong?

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