I frequently receive a "connection time out" message and can neither send nor receive email.

SOMETIMES exiting and reopening Thunderbird helps; SOMETIMES frequently checking for new mail and/or hitting the send button helps -- and sometimes nothing helps, not even rebooting. My internet connection via my browser works, and I am able to open links in older emails even when I cannot send or receive.
I am using 24.6.0 with Win 7 Ultimate.

Anti virus as you are probably aware operates on many different levels. The most obvious have been closed off. Lets try the second most obvious, real time scanning.
I have no idea what you use and they all use different terminology for basically the same things, so you will have to read between the lines a bit.
You have disabled the email scanning, now create an exception in the anti virus real time scanner for your [https://support.mozilla.org/en-US/kb/profiles-tb#w_where-is-my-profile-stored Thunderbird profile] folders.
Thunderbird uses a single file per folder to store mail and the anti virus can slow things to a crawl scanning those very large files every-time something is added or removed or a folder is changed. An exception means that does not happen and the folder is only scanned when a "full system" scan is done. This does not stop memory scanning or scanning of attachments when they are opened.

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