I get an error message when I try to save my images in Photoshop CS6

I get an error message when I'm trying to save my images.  It reads as follows:
"Could not save because file is locked, you do not have necessary access permissions or another file is using it"
The file is not locked (I unlocked the image as a layer), I am the administrator, and it wasn't being used elsewhere.
This has happened with all the images I've worked on in the past 90 minutes.  Has anyone got a solution?   I've never gotten this message before

Check that you actually have write permissions on the drive you are trying to save to.  They can an do get changed.

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