I get this error message: only a single instance of this application can run

When I try to open my bank statement I get this message: only a single instance of this application can run.  Just wondering what that means,  and how do I open a file with adobe reader?

Adobe Reader | Edit | Preferences | Security (Advanced)
That is, start Adobe Reader.
Chose Preferences from the Edit menu
Look at the left hand side for Security (Advanced) and click on it
Now look for the option to turn off Protected Mode.

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