I just updated to 10.9.3. I now cannot open Mail - it comes up with an error window and suggests it may be incompatible with this OS. What is the fix for this? Thanks

When I try to open Mail from the launchbar it won't open and comes up with a window saying it may be incompatible with this version of OS X.
What is the answer to fix this?!

Backup for safety on at least two reliable drives.
Reinstall using the combo update at http://support.apple.com/kb/DL1746
You would be wise to quit all apps, disconnect all peripherals and preferably delete all email accounts before upgrading.

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