I keep getting "Mail Not Responding" and have to force quit

I can't even get to "Mail Doctor" because the spinning beachball starts up instantly.  I have to force quit to get it to stop.  Mail is working on all my other eight devices but not my primary iMac.  What the heck?

What OS version are you running? If 10.8/9 try the below.
Do a backup.
Quit Mail.
Go to Finder and select your user/home folder. With that Finder window as the front window, either select Finder/View/Show View options or go command - J.  When the View options opens, check ’Show Library Folder’. That should make your user library folder visible in your user/home folder. Go to Library/Containers/com.apple.mail.  Move the folder com.apple.mail to your desktop. You must move the entire folder, not just the contents.
Re-launch Mail and test. If the problem is solved, recreate any required Mail settings and import any emails you want to save from the folder on the desktop. You can then put the folder in the Trash. If the problem remains, return the folder to where you got it replacing the one that is there. 
Information learned from Linc Davis. Thanks to leonie for some information contained in this.

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